"Preparation not panic. We are prepared as a city and we are not going to panic," Adams said.
The CDC is projecting about 5,000 deaths could occur over the next two weeks with New York and New Jersey among the states expected to see the highest numbers.
Earlier this week, the city raised its COVID alert level from low to medium as the more contagious Omicron subvariant BA-2 continues to spread.
The mayor and city's health commissioner, Dr. Ashwin Vasan, have been speaking daily about the steadily rising numbers.
"What I'm most concerned about is that we are seeing rising cases not only here in New York, in this region, but all across the country we're seeing rising cases and as we've seen when you've got significant numbers of people who are unvaccinated or significant numbers of people who haven't gotten their booster, that puts you at more risk," Dr. Vasan said.
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Dr. Vasan said the city would seriously consider bringing back mask mandates and vaccine checks, once again, if hospitalizations continue to increase.
"We'd need to see our hospitalization rate jump above 10 per 100,000," Dr. Vasan said.
Currently, it is 7 per 100,000.
On Friday, Mayor Adams said he is not ready, yet, to reinstate a mask mandate for public schools K through 12.
As for vaccine mandates for schools in the fall, the Mayor said he would make a determination after sitting down with his medical team.