Cleveland is dealing with multiple injuries as it listed 20 players on Monday's injury report, twice as many as Denver.
The key one is Browns quarterback Baker Mayfield, who was ruled out Wednesday after he aggravated the partially torn labrum Sunday he injured in his left shoulder Sept. 19. Mayfield said the initial injury was a complete tear of the labrum.
Mayfield reportedly was told by team doctors and from a second opinion that he should not play Thursday. He could return as soon as Oct. 31 against the Steelers.
Mayfield, the No. 1 overall pick in 2018, is 116-for-173 passing (67.1 percent) for 1,474 yards, six touchdowns, three interceptions, and a 97.8 passer rating this season.
Denver holds a 24-6 record in the all-time series against the Browns, winning 12 of the past 13 contests.
The Browns have lost two consecutive games, the Broncos have lost three in a row.
The Browns also have injury issues at running back. Already without Nick Chubb, the Browns lost Kareem Hunt to a leg injury during the fourth quarter Sunday. Chubb has been ruled out of the Broncos game, and Hunt was placed on the injured reserve.
Cleveland activated running back John Kelly to join D'Ernest Johnson and Demetric Felton in the backfield. Johnson has run for 11 yards on three carries, while Felton has caught eight of nine targets for 90 yards and a touchdown.
Also placed on IR was Browns linebacker Jeremiah Owusu-Koramoah, which means he and Hunt will miss at least three games.
On the other side, the Broncos are expected to start Teddy Bridgewater at quarterback despite suffering a foot injury Sunday against the Raiders. Bridgewater threw three interceptions, lost a fumble, was sacked five times, and suffered 17 hits against the Raiders.
Bridgewater is 139-for-198 passing (70.2 percent) for 1,514 yards with 10 touchdowns, four interceptions, and a 100.9 passer rating this season.
Cleveland's Myles Garrett leads the NFL in sacks with 8.0, which could cause problems for Bridgewater in this contest.
The Browns are 7-3 against the spread (ATS) in their past 10 Thursday games.
The over is 4-1 in the Broncos' past five games following a straight-up loss.
DENVER BRONCOS @ CLEVELAND BROWNS (8:20 p.m. ET Thursday, FOX)
Point spread: Browns -3 (favored to win by 3 or more points; otherwise Broncos cover)
Total scoring over/under: 42.5 points scored by both teams combined
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