Nancy Guthrie case update: Investigators searching for new leads as unidentified DNA remains key focus

NEW YORK - Nearly three weeks after Nancy Guthrie’s disappearance, law enforcement agencies say the search has entered a phase of traditional detective work, while forensic experts highlight how unidentified DNA could prove pivotal.

Investigators focusing on traditional detective work

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Officials with the Pima County Sheriff’s Department and FBI described current efforts in the Nancy Guthrie case as "gumshoe detective work," emphasizing methodical follow-ups rather than dramatic developments.

Authorities continue to urge the public to think about people they haven’t seen recently or any disruptions in daily routines that seem out of place, saying such insights could help investigators narrow the focus.

Investigators have reiterated that no shift to a confirmed "burglary-gone-wrong" scenario has been announced, despite widespread social media speculation. Officials also have not said whether the case appears targeted or random.

A suspect description remains a focus of the investigation, with law enforcement noting a person of interest seen near the area matching certain physical characteristics and clothing.

Unidentified DNA evidence could be key

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In a separate FOX 5 NY interview, a criminal defense expert explained how unidentified DNA evidence — if linked to a known individual — could significantly narrow the suspect pool and provide a crucial break.

The lawyer noted that if the DNA can be matched to someone, it may lead investigators closer to answers. But if the DNA cannot be identified, it could leave important questions unresolved and complicate the case.

Experts say forensic evidence in cases like this often becomes a central component as investigators move beyond initial search efforts.

What's next:

Authorities continue to ask for tips as work on the case proceeds. There have been no reported arrests, and investigators say the public’s help remains important.