The fire at 71-02 162 Street broke out at about 4:34 a.m. Firefighters responded to heavy flames inside a heavily cluttered apartment, said fire officials.
Firefighters were able to put the blaze under control by 5:21 a.m.
The victims- a 75-year-old female and an 81-year-old male- were pronounced dead at the scene. One person suffered a non-life-threatening injury.
An investigation into the cause of the fire was underway.