Flames engulfed the building located at 2309 Holland Ave. Friday just after 6 a.m.
According to officials, the fire started on the top floor, and increased to three alarms.
Thirty-three units with 138 firefighters were dispatched to the scene.
One person was critically injured, one suffered serious life-threatening injuries, and two others suffered serious non-life-threatening injuries, officials said. One other person suffered minor injuries.