Police are looking for Justin Soriano, 40, who is described as 6 feet 2 inches and 215 pounds.
Just after 1 a.m. on Sunday, officers responded to a 911 call of a woman shot on West 128th Street. Cops found Shanice Young, 31, with a gunshot wound to the head.
EMS took the woman to NYC Health & Hospitals/Harlem, where she was pronounced dead.
If you have any information about the shooting or where Soriano is, you can contact NYPD's Crime Stoppers at 800-577-8477 (English), 888-577-4782 (Español), CrimesStoppers.NYPDonline.org, or Twitter @NYPDTips.