According to authorities, the victim was in front of 2628 Third Avenue at around 6 p.m. with a group of her friends when she got into a verbal dispute with the suspect.
The dispute escalated into a physical confrontation and the girl and her friends began to attack the man, punching him in the head and chest.
The suspect then produced a knife and stabbed the girl in the neck and torso several times before running away on a scooter.
EMS took the victim to Harlem Hospital in serious but stable condition.
The suspect is described as a Hispanic male, between 20 and 30 years old, last seen wearing a red cap and all dark clothing.
Anyone with information in regard to this incident is asked to call the NYPD's Crime Stoppers Hotline at 1-800-577-TIPS (8477) or for Spanish, 1-888-57-PISTA (74782). The public can also submit their tips by logging onto the CrimeStoppers website at WWW.NYPDCRIMESTOPPERS.COM, on Twitter @NYPDTips.
Police say all calls are strictly confidential.