Statistics from 2018 were released on Monday by the Centers for Disease Control and Prevention.
The analysis was published in the journal Sexually Transmitted Diseases (STI).
The data show there were nearly 68 million STIs on any given day and 26 million newly acquired STIs in 2018.
Nearly one in two incident STIs were acquired by people aged 15 to 24 years old.
Federal authorities estimate that sexually transmitted diseases cost the healthcare system billions of dollars annually and those acquired in 2018 alone will add $16 billion in direct lifetime medical costs.
Women account for a disproportionate burden of severe STI outcomes and medical costs, according to the report.
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The authors recommend STI express clinics that allow walk-in STI testing and treatment without a full clinical exam.
They also suggest that pharmacies and retail health clinics be able to provide new access points for STI services, such as on-site testing and treatment.
Telehealth/telemedicine is also recommended as an especially critical component to STI services in rural areas.